Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases

Name: Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases
SKU: 22206823
Price: 449.00 NZD
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Hardback

Series:

Current Topics in Microbiology and Immunology

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Description

This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.

Author Biography:

Michael B.A. Oldstone has been a successful series editor, volume editor and author of Current Topics in Microbiology and Immunology for several decades. He is a professor based at The Scripps Research Institute, La Jolla, CA, and a member of the National Academy of Sciences. Hugh Rosen is a professor at The Scripps Research Institute, La Jolla, CA, USA.

Release date NZ

April 29th, 2014

Audience

Professional & Vocational

Contributors

Edited by Hugh Rosen
Edited by Michael B.A. Oldstone

Illustrations

22 Illustrations, color; 5 Illustrations, black and white; VII, 184 p. 27 illus., 22 illus. in color.

Pages

184

Series

Current Topics in Microbiology and Immunology

Dimensions

155x235x15

ISBN-13

9783319058788

Product ID

22206823

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Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases

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