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HIV-1 Latency

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Description

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.

Author Biography:

Guido Silvestri Emory University School of Medicine, Atlanta, GA 30329, USA gsilves@emory.edu Mathias Lichterfeld The Brigham and Women’s Hospital and the Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA MLICHTERFELD@mgh.harvard.edu
Release date NZ
December 10th, 2019
Audience
  • Professional & Vocational
Contributors
  • Edited by Guido Silvestri
  • Edited by Mathias Lichterfeld
Edition
Softcover reprint of the original 1st ed. 2018
Illustrations
VII, 248 p.
Pages
248
ISBN-13
9783030132149
Product ID
31691117

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