Advanced technologies such as robotics, 5G mobile communications, IoT, cloud computing and wireless sensor networks have had a huge impact and influence on manufacturing, with an increased collaboration between humans and smart systems. As the manufacturing process becomes more automated using real-time data, communication systems, Artificial Intelligence (AI) techniques and robotics feed data back into the manufacturing process. This enables the design of products that are more customized and personal, and leads to a more competitive, efficient and value-added production process by reacting more quickly to technical or human errors to avoid product and system damage while increasing workplace safety, and reducing waste, pollution, and associated costs. This edited book covers challenges, concepts, systems, architectures, technologies, and design characteristics of human-machine cooperation and interaction systems in smart manufacturing environments using state of the art technologies including AI, 5G, IoTs, Blockchains, CPS, sensing, automation and robotics. The book is aimed at researchers and engineers working on the applications of robotics and automation, HMI, HCI, CPS, sensing, information and communications technology, data science, ML/DL/AI, AR/VR, cybersecurity and electronics. It is also a useful reference for advanced students and lecturers in these fields, and will appeal to manufacturers and automation system developers.