Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Name: Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models
SKU: 24586643
Price: 168.00 NZD
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Hardback

Series:

Lecture Notes in Computational Science and Engineering

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Description

Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide an accessible introduction to the mathematical methods needed to deal with these models. They emphasize the use of numerical methods and provide sufficient details for the reader to implement the models and thereby study the effect of various drugs. Examples in the text include stochastic calcium release from internal storage systems in cells, as well as stochastic models of the transmembrane potential. Well known Markov models are studied and a systematic approach to including the effect of mutations is presented. Lastly, the book shows how to derive the optimal properties of a theoretical model of a drug for a given mutation defined in terms of a Markov model.

Release date NZ

April 20th, 2016

Author

Audience

Postgraduate, Research & Scholarly

Edition

1st ed. 2016

Illustrations

30 Illustrations, color; 99 Illustrations, black and white; XVI, 261 p. 129 illus., 30 illus. in color.

Pages

261

Series

Lecture Notes in Computational Science and Engineering

Dimensions

155x235x18

ISBN-13

9783319300290

Product ID

24586643

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