The known greatest tragedy in life is life that fails to fulfill its reason for existence. That might not shock you because many of us, perhaps unwilling to admit it, try hard as we can to forget it, suffer from this affliction to the extent that we have lost touch with the reason of our existence. It is a grim reality that we, humanity live with a silent desperation, and some of us meet our end haunted by the vague feeling that we have missed the essence of reality. As a collective, humanity grapples with a pervasive ignorance of reason for existence, permeating through nations, societies, communities, organizations, friendships, marriages, clubs, religions, tribes, and even down to individual creations. This ignorance of reason for existence breeds confusion, frustration, discouragement, and disillusionment. The world has transformed into a breeding ground for wars, massacres, hatred, stress, depression, hopelessness, and fear. Earth itself resembles a mother whose offspring, in this case, humanity, has lost the understanding of the rationale behind all aspects of life. A historical perspective reveals that when humanity loses its sense of knowledge of reason for existence, the value of life diminishes, and the race to conform with the majority intensifies. A cursory glance at both past and present events paints a grim picture that demands our attention. Television screens daily broadcast a flood of distressing images-bloodshed, death, diplomacy, conflict, hatred, fear, poverty, starvation, rape, genocide, refugees, human migration, natural disasters, bombings, economic uncertainty, immigration, corporate corruption, moral decay, sexual revolution, and clashes of counter cultures. Deep-seated ideologies crumble in the face of revolutionary changes. Sacred religious institutions morally decay under social pressures. Nations experience political re-engineering, frustration of traditional systems, social unrest, economic uncertainties, and institutionalized corruption. We construct buildings only to destroy them, develop weapons only to turn them against ourselves, invent healing medicines but withhold them from the sick, and enhance global communication through the internet only to destroy the moral principles and convictions of our children and their children's children. True liberation from this known greatest tragedy lies in re-capturing the reason for existence behind everything, particularly our own existence, and committing to its fulfillment.