This new, second edition of the definitive and highly regarded textbook provides a comprehensive review of vasculitisa fascinating array of life-threatening and minor conditions caused by inflammatory syndromes and diseases that affect the blood vessels. Vasculitis , Second Edition uniquely brings together concepts from both the biological and clinical aspects of vasculitis. Research in clinical immunology now invigorates the entire area of vasculitis, and shapes a rational approach to pathogenesis, diagnosis, and treatment, which is the substance of this text. Over 40 chapters cover known vasculitis conditions, and are illustrated with numerous full-color photographs of clinical and pathologic findings, diagrams, and tables. New chapters include the pathology of vasculitis, autoantibodies, animal models of vasculitis, and PET scanning. Separate sections are devoted to basic science, clinical manifestations commonly seen in vasculitis, imaging and percutaneous interventions, individual diseases and syndromes as well as conditions which can mimic vasculitis. The authors have been chosen based on their unique experiences with vasculitic conditions.
Many of the conditions are rare, and it is the exceptional clinician who has much experience with more than a few of these; thus, drawing upon authors from all over the world has enabled the editors to provide informed discussions of all of them.
Table of Contents
1. Classification of Vasculitic Syndromes; 2. Epidemiology of Vasculitis; 3. Hypersensitivity; 4. Biology of Endothelial Cells; 5. Complement; 6. Autoantibodies in Vasculitis; 7. Pathogenesis of Vasculitis; 8. Animal Models of Vasculitis; 9. Pathlology of Vasculitis; 10. Cutaneous Manifestations; 11. Oral Ulcers; 12. Ocular Manifestations of Systemic Vasculitis; 13. Cardiopulmonary Manifestations of Vasculitis; 14. Vascullitic Neuropathy; 15. GI Manifestations; 16. Renal Manifestations; 17. Digital Ischaemia and Raynaud's Phenomenon; 18. Angiography (Invasive and MRA), Ultrasound, Cross-sectional Imaging in Vasculitis; 19. PET Scanning; 20. An Approach to the Adult with Suspected Vasculitis; 21. An Approach to the Child with Suspected Vasculitis; 22. Assessment of Disease Activity and Damage; 23. Giant Cell Arteritis and Polymyalgia Rheumatica; 24. Takayasu's Arteritis; 25. Tropical Aortitis (Tropical Vasculitis) and Lepromatous Vasculitis; 26. Polyarteritis Nodosa; 27. Microscopic Polyangitis; 28. Cutaneous Polyarteritis; 29. Kawasaki Disease; 30. Wegener's Granulomatosis - Pathogenesis; 31. Wegener's Granulomatosis - Clinical and Immunodiagnostic Aspects; 32. Wegener's Granulomatosis - Treatment; 33. Churg-Strauss Syndrome; 34. Vasculitis in Primary Connective Tissue Diseases; 35. Behcet's Syndrome: Pathogenesis, Clinical Manifestations and Treatment (including immunogenetics); 36. Juvenile Behcet's Syndrome; 37. Vasulitis of the Central Nerbous Systems; 38. Thromboangitis Obliterans (Buerger's Disease); 39. Ctaneous Leukocytoclastic Vasculitis; 40. Henoch-Schonlein Purpura; 41. Cryoglobulinemic Vasculitis; 42. Miscellaneous Sorms of Vasculitis (including vasculitis in infection); 43. Drug-Induced Vasculitis; 44. Experimental Therapies for Vasculitis; 45. Antiphospholipid Syndrome; 46. Imitators of Vasculitis