The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption, Volume 136 in the International Review of Neurobiology series, provides an overview of the top candidate neuropeptides in the modulation of alcohol and drug abuse, also covering eating disorders and obesity. Topics covered in this latest release include Corticotropin Releasing Factor (CRF) and Addictive Behaviors, Dynorphin/Kappa Opioid Receptor Signaling in Pre-clinical Models of Alcohol, Drug, and Food Addiction, The Role of Ghrelin Signaling in Additive Behaviors, The Role of the Melanocortin System in Drug and Eating Disorders, Substance P and the Neurokinin-1 Receptor: The New CRH, and the Role of Neuropeptide Y (NPY) in Drug and Eating Disorders.
The book uniquely highlights the overlapping central mechanisms that contribute to both drug and alcohol abuse and eating disorders.
Todd E. Thiele joined Department of Psychology & Neuroscience at the University of North Carolina in 2001, where he has developed over the years the main objective of his work: to identify the neurobiological mechanisms in the brain that drive excessive alcohol (ethanol) consumption, and to identify the plastic changes that occur in the brain during the transition to ethanol dependence. To address these questions, he has focused on two neurobiological systems. One system integrating emotional responses, and involves a functionally interconnected set of brain regions often referred to as the extended amygdala. The second system involves brain circuitry modulating motivated behaviors associated with the acquisition and consumption of natural rewards. Converging evidence, both from the pre-clinical and clinical literature, suggests that ethanol usurps or "hijacks" the brain neurocircuitry that regulates emotions and responses to natural rewards, causing long-term changes that are associated with abnormal function. These changes trigger negative emotions and cause natural rewards to lose their reinforcing value, both outcomes which are thought to trigger uncontrolled ethanol intake. His hope is that by identifying how the brain changes over the course of heavy ethanol use, he may help identify pharmaceutical approaches that may prevent individuals that abuse ethanol from progressing to a state of dependence.