Bruce Yandle is a teacher, writer, speaker, and consultant on economics and political economy. He has worked in industry, academia, and government, serving in many roles and interacting with a variety of audiences. These experiences have directly impacted his scholarship on regulation and macroeconomic policy. Policy making is complex. It is not simply the result of high-minded reformers seeking to do good, nor is it only the pernicious influence of special interest groups seeking to exploit the power of government. Rather, it is an often odd and unintentional combination of the two. In the early 1980s, Yandle aptly named this theory of regulation "Bootleggers and Baptists" to describe how seemingly opposing forces join together in support of similar government policies. This theory, as well as Yandle's other scholarly contributions, has inspired generations of academics and policy analysts by advancing a nuanced yet approachable analysis of regulation. This impact is magnified by his gracious, humble, and purposeful demeanor. In honor of Yandle's 85th birthday in 2018, a gathering of colleagues and students convened to reflect on and honor his productive career and to advance research inspired by his work. This Festschrift, edited by Donald J. Boudreaux and Roger Meiners, includes original essays and reflections, drafted for and discussed at the 2018 symposium, that pay tribute to Yandle, a scholar of unusual ability as a teacher and researcher. The volume concludes with an essay by Yandle himself, looking back on his career and the state of economics and policy making today and issuing a call to action for the next generation of scholars and teachers in political economy. The Legacy of Bruce Yandle should be of interest to anyone inspired by Yandle's research as well as students, scholars, and policymakers interested in the real-world application of economic analysis to regulation and other policies.