Patricia Frank is President of Patricia Frank &Associates, Inc., a consulting firm founded in 1993 that assistscompanies in the development and registration of human andveterinary pharmaceutical agents. She is a past president of boththe American College of Toxicology and the Roundtable of ToxicologyConsultants. M. Alice Ottoboni lectures, writes, and consults in thefield of toxicology. As Staff Toxicologist with the CaliforniaState Department of Public Health for over twenty years, sheoriginated, designed, and performed numerous toxicological studiesof environmental factors of importance to public health. She is theauthor of the previous editions of The Dose Makes thePoison.