A growing body of literature indicates that diseases can affect women and men differently. As sex differences extend far beyond biology, it is crucial to adopt a bicultural approach towards understanding human disease patterns and processes. This book synthesizes modern medical research with paleopathological investigations. Conditions such as osteoporosis and osteopenia, iron deficiency anaemia, infection and immune reactivity and trauma are explored. Recognizing the relationship between these conditions and aspects of sex and gender in past populations assists in the formulation of models from which modern disease processes can be better understood. Exploring the differences will provide provocative ideas for all those in physical anthropology, archaeology, evolutionary biology, history of medicine and women's studies interested in how sex and gender impacts on disease.