The consequences of current experiments in socio-economic global transformation are not favorable for Russia. At the same time, the optimum development trajectory of the country has not been clearly delineated by either theorists or practitioners either in political or socio-economic terms. The paradigm of the market economy has become outdated and is now an object of exploitation by global transnational corporations. There is a need for interdisciplinary consolidation, which can become the basis for understanding the role of the political and economic components of knowledge about the economy and society, the necessity and possibility for its improvement, and its application for the benefit of the country and the world, not excluding departure from obsolete stereotypes while maintaining the basic principles of logic and morality. It is time to redirect the apparatus of economic science to achieve real national and global welfare by eliminating irrational practices characteristic of both government intervention and private entrepreneurship, aimed at the realization of bureaucratic and oligarchic interests.