Progress in Heterocyclic Chemistry (PHC), Volume 27, is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year’s literature on heterocyclic chemistry and articles on new developing topics of particular interest to heterocyclic chemists. The highlight chapters in Volume 27 are all written by leading researchers and these chapters constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2014. Additional articles in this volume are “The Use of Propargyl Vinyl Ethers in Heterocycle Synthesis” and “Recent Progress of Phosphonium Coupling in Heterocyclic and Medicinal Chemistry." As with previous volumes in the series, Volume 27 will enable academic and industrial chemists, and advanced students, to keep abreast of developments in heterocyclic chemistry in a convenient way.