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Optimized Response-Adaptive Clinical Trials by Thomas Ondra
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Optimized Response-Adaptive Clinical Trials

Sequential Treatment Allocation Based on Markov Decision Problems
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Description

Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.

Author Biography:

Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna.
Release date NZ
December 18th, 2014
Author
Audience
  • Professional & Vocational
Illustrations
14 Illustrations, black and white; XV, 102 p. 14 illus.
Pages
102
ISBN-13
9783658083434
Product ID
26926132

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