For as long as humanity has existed, there have been 'Others' among us: Witches, Vampires and Shape-Shifters who are soldiers in the eternal war between Light and Dark. Light Others protect mankind from Dark Others, who plague and torture humans.

For over 1000 years a truce has existed, upheld by underground forces: the soldiers of the Light (Night Watch) and the soldiers of the Dark (Day Watch).

Ancient prophecy foretells that one day the Great One will arrive and end the threat of an apocalyptic battle between Light and Dark Others. That day has come, and somewhere in Moscow a Nightwatch team race to find and protect the Great One from the DayWatch vampires who seek to plunge the world into darkness. Whoever reaches the Great One first will hold the balance of power in their hands and control the fate of humanity.