This book explores the various applications of systemic understanding in practice. Each chapter covers diverse working contexts and existential life dilemmas, tackling subjects such as: systemic work with individuals, single session family therapy, experiences of adult longing, the therapeutic relationship as a form of love, working systemically with experiences of marginalisation, cultural difference and diversity, the integration of recent neuroscience developments with systemic therapy with couples, the role of forgiveness and the spiritual dimension in therapy. Throughout, this book promotes hope by presenting new horizons and providing room for reflection on uncertainty, change, opportunities, inter-connections and differences. Theoretical expansion of these existential issues lies both at the heart of systemic work and on the leading edge of research and theory-practice linking, showing how the integration of research with new developments across the broader fieldsof psychotherapy and counselling can be held within a systemic relational umbrella.