This volume explores how the principles and values of pragmatic philosophy serve as orienting perspectives for critical thinking in contemporary psychotherapy and clinical practice. Drawing on the contributions of William James and John Dewey, Neuroscience, Psychotherapy, and Clinical Pragmatism introduces a model of clinical pragmatism emphasizing the individuality of the person, open-ended dialogue, experiential learning, and the practical outcomes of ideas and methods. In a second part, chapters show how recent developments in neuroscience and interpersonal neurobiology deepen our understanding of change and growth in accord with the principles of clinical pragmatism. Finally, the volume reviews paradigms of psychotherapy across the psychodynamic, behavioral, cognitive, and humanistic traditions. Case studies show how the pluralist orientation of clinical pragmatism enlarges concepts of therapeutic action. This text has been written for psychotherapists as well as scholars, educators, and trainees in the fields of psychiatry, clinical psychology, counseling, and social work.