Interdisciplinary co-operation between epileptologists, neuroradiologists, psychologists and neurosurgeons is the most fundamental prerequisite for localising and performing targeted resections of epileptogenic foci from patients with focal therapy resistant epilepsy. Worldwide there has been a steady increase in the number of epilepsy surgery centres, and in the number of operations performed on children and babies. A systematic neuropathological description is presented here involving macroscopic and histological findings. In this book, a systematic documentation of characteristic as well as rarer alterations is presented involving 444 patients who had been operated on in Germany between 1990 and 1997 at the Bethel Epilepsy Centre in Bielefeld. It includes 257 patients with temporal lobes (TLE) and 187 patients with extratemporal epilepsy (ETE).