Neurofibromatosis Type 1

Name: Neurofibromatosis Type 1
SKU: 20798640
Price: 583.00 NZD
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Molecular and Cellular Biology

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Description

Neurofibromatosis type 1 (NF1), caused by mutational inactivation of the NF1 tumour suppressor gene, is one of the most common dominantly inherited human disorders, affecting 1 in 3000 individuals worldwide. This book presents in concise fashion, but as comprehensively as possible, our current state of knowledge on the molecular genetics, molecular biology and cellular biology of this tumour predisposition syndrome. Written by internationally recognized experts in the field, the 44 chapters that constitute this edited volume provide the reader with a broad overview of the clinical features of the disease, the structure and expression of the NF1 gene, its germ line and somatic mutational spectra and genotype-phenotype relationships, the structure and function of its protein product (neurofibromin), NF1 modifying loci, the molecular pathology of NF1-associated tumours, animal models of the disease, psycho-social aspects and future prospects for therapeutic treatment.

Release date NZ

January 30th, 2013

Audience

Professional & Vocational

Contributors

Edited by David N. Cooper
Edited by Meena Upadhyaya

Edition

2012 ed.

Illustrations

XVI, 717 p.

Pages

717

Dimensions

155x235x43

ISBN-13

9783642328633

Product ID

20798640

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