Written by experts at the forefront of current research and clinical practice, this volume provides evidence-based guidelines for safe, effective, and rational drug therapy in newborns, children, and adolescents. Coverage includes specific recommendations for all major drug classes and diseases, a detailed section on drugs and the newborn, and chapters on specific treatment settings such as the pediatric intensive care unit and emergency room. Also included are chapters on adverse effects and interactions and state-of-the-art discussions on pharmacokinetics, pharmacodynamics, pharmacogenetics, drug development, and clinical drug trials in infants and children. Appendices include a neonatal formulary and a pediatric formulary. FEATURES: Evidenced-based discussion of drugs in pediatric populations Expert researchers/contributors Contains chapters on adverse effects and interactions and state-of-the-art discussions on pharmacokinetics, pharmacodynamics, pharmacogenetics, drug development, and clinical drug trials in infants and children

Table of Contents

I. GENERAL PRINCIPLES INTRODUCTION AND HISTORICAL PERSPECTIVES Sumner J. Yaffe and Jacob V. Aranda CLINICAL PHARMACOKINETICS IN INFANTS AND CHILDREN Edmund V. Capparelli DRUG ACTION AND THERAPY IN THE INFANT AND CHILD Ralph E. Kauffman DRUG METABOLISM AND DISPOSITION IN INFANTS AND CHILDREN Anders Rane PHARMACOGENETICS, PHARMACOGENOMICS, AND PHARMACOPROTEOMICS J. Steven Leeder COMPLIANCE WITH PEDIATRIC MEDICATION REGIMENS Hakan Ergun and Daniel A.C. Frattarelli CLINICAL TRIALS INVOLVING CHILDREN: HISTORY, RATIONALE, AND TECHNICAL CONSIDERATIONS Steven Hirschfeld ETHICS OF DRUG RESEARCH IN PEDIATRIC POPULATIONS Sanford N. Cohen and Bruce L. Russell THERAPEUTIC DRUG MONITORING Alexander A. Vinks and Philip D. Walson DRUG FORMULATIONS Milap C. Nahata II. DRUGS AND THE NEWBORN OVERVIEW OF DRUGS IN PREGNANCY Donald R. Mattison and John F. Young PLACENTAL TRANSFER OF DRUGS Rada Boskovic and Gideon Koren PERINATAL ORIGINS OF ADULT DEFECTS IN DRUG METABOLISM Bernard H. Shapiro PRINCIPLES OF NEONATAL PHARMACOLOGY Jeffrey L. Blumer and Michael D. Reed RENAL FUNCTION AND EXCRETION OF DRUGS IN THE NEWBORN John van den Anker THE EXCRETION OF DRUGS AND CHEMICALS IN HUMAN MILK Cheston M. Berlin DRUGS FOR HYPERBILIRUBINEMIA David K. Stevenson, Susan R. Hintz, Ronald J. Wong, and Hendrik J. Vremen DRUGS AND LUNG DEVELOPMENT Alan H. Jobe DRUGS IN NEONATAL APNEA J.M. Lopez and Jacob V. Aranda DRUGS AND PERINATAL BRAIN INJURY Maria Delivoria Papadopoulos, Agustin Legido, and Om Prakash Mishra ANTIRETROVIRAL PHARMACOLOGY IN PREGNANT WOMEN AND NEWBORNS Mark Mirochnick III. DRUGS IN SPECIAL POPULATIONS AND SETTINGS THERAPEUTIC APPLICATIONS IN PEDIATRIC INTENSIVE CARE Mary Lieh-Lai and Ashok Sarnaik DRUG THERAPY IN THE PEDIATRIC EMERGENCY DEPARTMENT Shannon Manzi and Michael Shannon DRUG THERAPY IN THE ADOLESCENT Ian M. Paul and Richard L. Levine TOPICAL MEDICATIONS Fasahat H. Hamzavi and George J. Murakawa OPHTHALMOLOGIC DRUGS IN INFANTS AND CHILDREN John D. Roarty IV. SPECIFIC DRUGS SULFONAMIDES AND QUINOLONES Jacob V. Aranda, et al. PENICILLIN, BETA-LACTAM INHIBITORS, CEPHALOPSPORINS Sumathi Nambiar and William J. Rodriguez AMINOGLYCOSIDES AND GLYCOPEPTIDES Matthijs de Hoog and John van den Anker MACROLIDES, CHLORAMPHENICOL, AND TETRACYCLINES Basim Asmar ANTHELMINTHIC DRUGS IN CHILDREN George C.F. Hsieh, Vincent C. Fan, and Peter J. Hotez ANTI-TUBERCULOSIS DRUGS Alexander O. Tuazon ANTIFUNGAL AGENTS William J. Steinbach and John R. Perfect