Thoroughly revised and updated, this Third Edition is the most comprehensive, current reference on lung cancer, with contributions from the world's foremost surgeons, radiation oncologists, medical oncologists, pulmonologists, and basic scientists. This edition includes sixteen new chapters and has been reorganized for greater clinical emphasis.Coverage includes complete information on combined modality treatments for small cell and non-small cell lung cancer and on complications of treatment and management of metastases. Emphasis is also given to early detection, screening, prevention, and new imaging techniques. A new editor, David Carbone, provides state-of-the-art coverage of the molecular genetics and biology of lung cancer. FEATURES: Most comprehensive lung cancer book on the market Stresses combined modality treatments from small cell and non-cell lung cancer as well as the manag ement of metastases and the complications of treatment Contributor base reflects international authorities in the field NEW TO THIS EDITION: Major reorganization of chapters to increase clinical emphasis 16 new chapters New editor, David Carbone, provides state-of-the-art coverage of the molecular genetics and biology of lung cance

Table of Contents

1. Etiology and Epidemiology The Etiology and Epidemiology of Lung Cancer David Schottenfeld Cigarette Smoke Damage to DNA and Other Biomolecules William A. Pryor and Koni Stone The Biology of Nicotine Addiction Neal Benowitz Genetic Susceptibility to Lung Cancer Ann G. Schwartz and Margaret Spitz Passive Tobacco Exposure and Lung Cancer Non Tobacco-Related Lung Carcinogenesis Ware G. Kuschner and Benson Tze-Ming Chen 2. Lung Cancer Biology Genomic Imbalances in Lung Cancer Pierre P. Massion Non Mutational Mechanisms of Gene Dysfunction Hirsch and Adi Gazdar M.D Chromosome 3 abnormalities John D. Minna Abnormalities of the Cell Cycle in Lung Cancer Fulvio Lonardo Receptor Kinase Abnormalities Rojo, Enriqueta Felip, and Jose Baselga Telomerase and Lung Cancer Jerry W. Shay Angiogenesis and Lung Cancer Michael S. O'Reilly Mouse Models of Lung Cancer Tyler Jacks and Ambra Pozzi 3. Screening/Early Detection/Prevention The Early Detection of Lung Cancer Using Bronchsocopy and Cytologic Analysis Thomas L. Petty and Stephen Lam and York Miller Molecular Techniques of Early Detection Hirsch (8) and Ari Gazdar Lung Cancer Screening: Helical CT Screening using Two Approaches Claudia Henschke, David Yankelewitz, Olli S. Miettinen Chemoprevention of Lung Cancer Scott Lippman, Edward Kim and Waun Ki Hong 4. Pathology and Molecular Classification The Classification, Histology, Cytology, and Electron Microscopy of Lung Cancer Wilbert Franklin and Adriana L. Gonzalez The Molecular Classification of Lung Cancer Choon-Taek Lee and David Carbone Molecular Prognostication of Lung Cancer David G. Beer The Techniques and Applications of Tissue Microdissection John W Gillespie, RF Bonner, LA Liotta, and MR Emmert-Buck 5. Clinical Presentation, Diagnosis, Staging, and Prognosis The Clinical Presentation of Non Small Cell Lung Cancer Antoinette J. Wozniak The Clinical Presentation of Small Cell Lung Cancer Greg Masters The Imaging of Lung Cancer Leslie E. Quint, IR Francis, and BH Gross Special Imaging including PET and Special Antibody Scans like Octreotide Johan F. Vansteenkiste, Stroobants and Pieter Postmus Tissue Procurement: Bronchoscopic Techniques and Bronchoscopic Staging Gerard A. Silvestri Lung Cancer Staging in NSCLC including Preop and Intraoperative Techniques John R. Roberts Staging and Prognostic factors for Small Cell Lung Cancer John R. Murren and Athan Argiris The Medical Evaluation and Management of the Lung Cancer Patient Pre-Treatment Fernando J. Martinez, M. Iannettoni, and Jules Lin