Much ink has been spilled about kidney transplantation. Many books have been written on the subject and examined it from multiple aspects like the medical and scientific viewpoints, the ethical, legal, and psychological standpoints, or the policy perspectives. However, unlike previous manuscripts that focused on a particular facet or feature and researched it profoundly, this book's uniqueness is inherent in its all-encompassing nature. The novelty of this book is expressed in its comprehensiveness. It looks at kidney transplantation and donation from a bird's-eye view to give the reader a complete and inclusive description. This book might not be as thorough or exhaustive as previous works; nevertheless, it tackles different aspects of kidney transplantation and donation and provides the reader with a broad view of the subject. To name a few, the interested reader will gain knowledge about tissue typing, system analysis, organ allocation policies and strategies, and ethical, legal, and policy issues. The book has an appeal to clinicians and the lay public alike. Though it discusses medical terms, point-system policies, or mathematical models, it presents a clear and readable version that guides the expert and the layman through the realm of organ transplantation. The book starts with illustrating the background, the problems, and the technical terms to engage the reader with the complex field of organ transplantation. After the readers are familiar with transplantation's cornerstones, the book delves into specific issues like allocation policies and alternative proposals, vulnerable populations, community preferences, and balancing equity and efficiency. Eventually, the book comes full circle and suggests possible strategies to increase deceased donors' supply and use. In conclusion, the book demonstrates the importance of organ transplantation policies and the need for revision and improvement without being cumbersome and tedious.