Human Polyomaviruses Molecular and Clinical perspectives Edited by Kamel Khalili and Gerald L. Stoner Our understanding of human polyomaviruses has evolved profoundly in the last fifteen years, creating an urgent need for an updated resource. Drs. Khalili and Stoner have collected the contributions of renowned researchers and clinicians in this cutting-edge volume. Human Polyomaviruses: Molecular and Clinical Perspectives presents in-depth analyses, comprehensive reviews, and timely assessments of recent discoveries and ongoing controversies focused on these important viral pathogens. Beginning with an historical perspective, this book covers up-to-date investigations into the molecular biology and pathogenesis of human polyomaviruses. All aspects of these persistent infections are subsequently covered, including clinical issues, from diagnosis to information on treatment and drug trials. Central topics are: - BK virus- JC virus- Simian virus 40 (SV40) and its potential as a human pathogen- Progressive multifocal leukoencephalopathy (PML) This reference is a superb indoctrination for graduate students, medical students, high-level undergraduates, and anyone engaged in the study of DNA viruses and their molecular biology, evolution, transmission, and pathological potential.

Table of Contents

Preface. Contributors. Progressive Multifocal Leukoencephalopathy: The Discovery of a Neurologic Disease (K. Astrom). Papova Virions in Progressive Multifocal Leukoencephalopathy: A Discovery at the Interface of Neuropathology, Virology and Oncology (G. Zu Rhein). Progressive Multifocal Leukoencephalopathy: Cultivation and Characterization of the Etiologic Agent (D. Walker). Serendipity--The Fortuitous Discovery of BK Virus (W. Knowles). The Human Polyomaviruses: An Overview (M. Imperiale). Transcription and Replication in the Human Polyomaviruses (H. Kim, et al.). The Archetype Concept and Regulatory Region Rearrangement (Y. Yogo & C. Sugimoto). Synthesis and Assembly of Polyomavirus Virions (Y. Shishido--Hara & K. Nagashima). Cellular Receptors for the Polyomaviruses (W. Atwood). Latent and Persistent Polyomavirus Infection (K. Dorries). Clinical Progressive Multifocal Leukoencephalopathy: Diagnosis and Treatment (J. Berger & A. Nath). The Neuropathology and Pathogenesis of Progressive Multifocal Leukoencephalopathy (M. Mazlo, et al.). Laboratory Findings in Progressive Multifocal Leukoencephalopathy (T. Weber). Molecular Biology of BK Virus and Clinical and Basic Aspects of BK Virus Renal Infection (U. Moens & O. Rekvig). JC Virus in Experimental and Clinical Brain Tumorigenesis (L. Del Valle, et al.). Evidence for BK Virus as a Human Tumor Virus (A. Corallini, et al.). SV40 and Human Tumors (A. Arrington & J. Butel). Molecular Evolution and Epidemiology of JC Virus (H. Agostini, et al.). The Epidemiology of BK Virus and the Occurrence of Antigenic and Genomic Subtypes (W. Knowles). The Epidemiology of SV40 Infection Due to Contaminated Polio Vaccines: Relation of the Virus to Human Cancer (D. Rollison & K. Shah). The Immune Response to SV40, JCV and BKV (S. Tevethia & T. Schell). The Human Polyomaviruses: Past, Present, and Future (G. Stoner & R. Hubner).Index.