A rescue mission is launched!

The Japan Branch has fallen, and Guyver II has been utterly destroyed. Chronos is far from finished. Calling in the deadly "Lost Number Commandos," Guyot uses Makishima's estate as a temporary base and hatches a plot to tear apart Sho's life in any way possible.

Setting the city aflame, Sho's home is burned to the ground as his father, Tetsuro and Mizuki are taken captive. Now Sho must infiltrate Relic's Point, an immense Chronos base where the Guyver units were discovered and fearsome new Zoanoids are mass-produced. To rescue his friends and family, he is forced to team up with the Guyver III and a mysterious gun-toting reporter.

Standing before them is a team of five elite Hyper-Zoanoids constructed by Chronos' top scientist. This new breed of monster has the strength to absorb the Guyver's defenses, and may prove too much for the trio of heroes.