The study of bone fracture and healing is a very challenging job in orthopedic surgery. In the present perspective of this endeavor is to document of ever increasing growth factors and their respective roles to get a successful repaired bone. Therefore the present study envisage the healing of bone fractures and the role of growth factors like TGF-ß1, IGF-1, FGF, PDGF, VEGF and bone morphogenetic proteins-2 and 7 in healing mechanism. In this book a comparative efficacy of TGF-β1, IGF-1 and the combined application of TGF-β1 and IGF-1 was evaluated in augmentation of segmental bone healing. We observed that the combined application of TGF-β1 and IGF-1 stimulated the production of osteoblasts that transformed into osteocytes produced synergistic osteoinductive effect in augmentation of fracture healing and remodeling process in combo group as compared to apply singly. I want to express my sincere wishes to Dr. S. Sarkar and Prof. Subhashis Biswas for their inspiring attitude that increased the strength for such work. Finally I want to express my sincere gratitude to my wife Sipra and son Himanish for their constant support.