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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins on Hardback by Raphael Enoque Ferraz de Paiva
Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins on Hardback by Raphael Enoque Ferraz de Paiva
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

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Description

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.
Release date NZ
October 11th, 2018
Audience
  • Professional & Vocational
Edition
1st ed. 2018
Illustrations
38 Illustrations, color; 62 Illustrations, black and white; XXXIX, 151 p. 100 illus., 38 illus. in color.
Pages
151
ISBN-13
9783030008529
Product ID
28330879

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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins by Raphael Enoque Ferraz de Paiva
$295.00
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by Raphael Enoque Ferraz de Paiva ~ Paperback / softback
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