The authors of this book retell the political and economic history of East-Central Europe, the post-communist Balkans, and the Baltic states and speculate about their future from the vantage point of three competing forces operating in the region: territorial imperialism, globalization, and nationalism. Exposed to imperial aspirations, the geographic area from the Baltic Sea to the Black Sea has in the past 150 years been subject to alternating waves of globalization and nationalism. The nineteenth century Eastern European empires were open to forces of economic globalization, but all collapsed at the end of World War One. Emerging nation-states embraced the logic of Western-led globalization but were subjugated by Nazi and Soviet empires, which pursued policies of economic autarchy. The demise of the Soviet empire marked the revival of pre-1939 nation-states and the re-entry of forces of liberalism and globalization into the region, with multiple crises of economic transition, ethnic militancy, new forms of authoritarianism, and external security threats. By 2010 negative, nationalist-populist reactions against crises that globalization brought to Eastern Europe became the dominant political trend. The analysis involves the consideration about the very contemporary factors of Brexit and COVID, as well as Russia’s and China’s influences, and their effects on Eastern Europe.