We as authors are delighted for contributing this work for the scientific world. We believe we have addressed a solution for the formulation related problems of one of the commonly used medicine-furosemide through the gastroretentive novel drug delivery approach. We feel our work is different in maximal utilization of the concept of simultaneous optimization as compared with many other similar studies applying optimization principle. Thus, we recommend for readers of this book, the simultaneous optimization concept used here could be used as model study for other experimental researches inquiring simultaneous optimization for a number of process and formulation, dependent and independent variables for scholars and researchers across various disciplines; industrial pharmacy, applied chemistry, chemical engineering, food and drink technology, agriculture, ..