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Farnesyltransferase Inhibitors in Cancer Therapy

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Description

Cutting-edge researchers describe their efforts to design, synthesize, and evaluate the biological activities of farensyltransferase inhibitors (FTIs); geranylgeranyltransferase inhibitors (GGTIs) are also discussed as potential anticancer drugs. The authors survey in detail such inhibitors as CAAX box peptidomimetics, FPP mimics, and bisubstrate transition state analogs, and critically review their uses in combination with radiation and other cytotoxic agents, such as gemcitabine, cisplatin, and taxanes. Illuminating and richly detailed, Farnesyltransferase Inhibitors in Cancer Therapy constitutes today's standard reference for the pathbreaking use of FTIs and GGTIs in anticancer therapy and offers basic and clinical investigators a comprehensive treatment of the scientific and medical aspects of farnesyltransferase inhibitors.
Release date NZ
November 26th, 2012
Audience
  • Professional & Vocational
Contributors
  • Edited by Andrew D. Hamilton
  • Edited by Said M Sebti
Edition
Softcover reprint of the original 1st ed. 2001
Illustrations
xii, 280 p.
Pages
280
Dimensions
178x254x16
ISBN-13
9781468496062
Product ID
21580611

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