This work details with the design and development of fuzzy modelling for multi variable process in distillation column. Salient Features -Fuzzy modelling of distillation column using Takagi - Sugeno model. -Design a fuzzy model predictive control (FMPC) for multi variable control of distillation column -Optimization of the system with different optimization algorithms -Comparison of the results of distillation column controlled with conventional PI controller, Model Predictive Control and FMPC. -Development of neural network model for distillation column -Design of Adaptive Neuro Fuzzy Interference System (ANFIS) for distillation column and to control the parameters. -Comparison of the results of this system controlled with conventional PI controller, Model Predictive Control and ANFIS