In the third short story of the series The Adventures of ACE2, we continue with the Good the Bad and the Ugly as a new COVID-3 plan of viral dominion is launched. As the COVID-3 Gang becomes detected and the old ACE-2 Gang learns to reassemble they are assisted by new human heroes Phil and Ralph. Now COVID-3 becomes trapped and must urgently lead the rest of the dispersed Gang to find and test new ways to survive, infect and replicate. With a less evil plan they execute plans to assimilate new powers through exosomes, HIV and cancer. Now, having found a successor COVID-4 residing in a new cancer laden host they suddenly realize who their original Maker was. As COVID-3 deals with the old ACE-2 Gang now joined by the Exosome ECV-1, his Gang must face the potential annihilation scheme planned by two human heroes who uncover another hidden sinister agenda for world dominion. As the pandemic lockdown of COVID-2 heightens, the realization of its true Makers and origins comes to light. In eminent danger of being destroyed by a new process created by our human heroes, COVID-4 must separate from the COVID-3 team on a mission of viral dominion and to upgrade their Maker's lineage. But now there is an even more sinister agenda as the deadly ingested cancer RNA has ingested COVID-4. Follow the Good and the Bad as they all struggle for their survival.