This volume is a compilation of sixteen studies published by the author and his research team over the last twelve years regarding the work of neurobiologist Christofredo Jakob (1866-1956). Jakob was professor of neurobiology at the Faculty of Humanities and Educational Sciences of the University of La Plata and the Faculties of Medicine and of Philosophy and Letters of the University of Buenos Aires, Argentina. He made landmark discoveries on the visceral brain and the circuits of emotion, and suggested a tripartite system of neuronal hierarchical levels. He also studied the origin and ubiquitous function of the cerebral cortex, language pathophysiology, cerebellar neurobiology, consciousness, and neurophilosophy.