The information age is reshaping current socio-economic structures and processes and this book touches upon the nature of clusters in the fourth industrial revolution (Industry 4.0; I4.0). It focuses on the spatial perspective of digital business transformation and explores in natural context the interrelations between cluster and I4.0. It investigates the role of knowledge, business relations and policy in making cluster relevant for Industry 4.0 and uses the case study method and literature review to develop a conceptual framework outlining the functioning of Industry 4.0 cluster. This book argues that locally embedded knowledge accompanied by strong presence of industry and assisted by proper governance management facilitate the implementation of I4.0. The idiosyncrasies of Industry 4.0 impact also the functioning of cluster as they require more interdisciplinary integrative approach with the provision of industrial commons and development of related varieties. Natural processes of stretching of the cluster cannot be prevented, but should be harnessed for upgrading the core competences of cluster. This book can enrich existing literature on economic geography and regional studies by discussing the spatial aspects of digital transformation. It shows the cluster transformation as induced by the digital transformation, and will be of interest to researchers, academics, policymakers, and students who explore the regional and local development, competitiveness, or managerial aspects of fourth industrial revolution.