Measurement of the therapeutic and adverse effects of drugs remains a high priority for the pharmaceutical industry, particularly in proving clinical efficacy and safety, and in the evaluation and development of new drugs. Here, an international field of authors have provided a text devoted to the principles and practice of drug evaluation. Emphasis has been given to surrogate end points, peripheral vascular disease, the reliability of collection and interpretation of data and the identification, predictability and interpretation of drug interactions and adverse effects. This volume will be of enormous value to pharmacologists, cardiologists, psychiatrists and haematologists, as well as medical and research staff in industry and academia.