Table of Contents

#A Investigative Approaches to Organelle Disturbances.- #A-1 Investigation of ischaemic effects on subcellular structures by centrifugation methods.- #A-2 Investigation of subcellular derangements in human biopsy material.- #A-3 Analytical subcellular studies in alcoholic liver disease.- #A-4 Methodological approaches in studies of altered mitochondrial and peroxisomal ?-oxidation.- #A-5 Pharmacological and toxicological aspects of peroxisome proliferators.- #A-6 Studies on the mechanisms of changes produced in the liver, thyroid, pancreas and kidney by hypolipidaemic drugs and di-(2-ethylhexyl) phthalate.- #A-7 The use of cytochrome P-450 isoenzymes as an index of endoplasmic reticulum changes.- #A-8 Drug-induced mitochondrial proliferation.- #A-9 Ultrastructural morphometric/biochemical approaches to assessing metal-induced cell injury.- #A-10 Iron overload, lysosomes and free radicals.- #A-11 Glucocerebrosidase, a membrane-associated lysosomal enzyme deficient in Gaucher disease.- #A-12 Cytochemical techniques applied to whole tissue and tissue homogenates.- #NC(A) Supplementary Items.- #NC(A)-1 Immunoelectron microscopical localization of lysosomal hydrolases in normal and I-cell fibroblasts.- #B Approaches Depending on Surface Distinctions.- #B-1 Free-flow electrophoresis: its application to the separation of cells and cell membranes.- #B-2 Counter-current chromatography as a tool in subcellular studies.- #B-3 Flow cytometry: a tool in studying cellular derangements.- #B-4 Interaction of Paf-acether with the human platelet: receptor binding and pharmacology.- #NC(B) Supplementary Items.- #NC(B) Supplementary Items.- #C Plasma Membrane and Cytoskeleton.- #C-1 Membrane-mediated cytotoxicity: measurement of changes and their prevention by divalent cations.- #C-2 Complement-mediated plasma-membrane damage: effects on cell physiology, prospects of cell recovery and implications for disease mechanisms.- #C-3 Erythrocyte membrane derangements associated with sickle cell disease.- #C-4 The membrane-cytoskeletal axis in phagocytosing PMN- leucocytes and virally transformed fibroblasts.- #NC(C) Supplementary Items.- #NC(C)-1 Studies on cell injury: effects of ion regulation on cell membranes and the cytoskeleton.- #NC(C)-2 The glycoproteins and fluidity of multinodular goiter euthyroid plasma membranes.- #D Epithelial Membranes in Digestive Tissues.- #D-1 Gastroduodenal epithelial cells: the role of the apical membrane in mucosal protection.- #D-2 Structural and functional aspects of the intestinal brush border.- #D-3 Studies of the mechanisms of mucosal iron uptake.- #D-4 Pancreatic acinar cell plasma-membrane enzymes involved in stimulus-secretion coupling.- #NC(D) Supplementary Items.- #NC(D) Supplementary Items.- #E Studies Focused on Endocytosis, Proteases or Invasiveness.- #E-1 Receptor-mediated uptake of a toxin which binds to plasma-membrane ion channels.- #E-2 Lysosomal proteolysis in cultured hepatocytes.- #E-3 Hepatic processing of insulin: characterization and modulation.- #E-4 Receptor-mediated endocytosis in rat liver parenchymal and non-parenchyma1 cells, studied by means of subcellular fractionation in density gradients.- #E-5 Use of chromogenic peptide substrates in the study of proteolytic enzymes and mechanisms regulating them.- #E-6 Peptidases in connective tissue degradation and remodelling in reproductive and invasive tissues.- #E-7 Brain tumour cell invasion: possible role of lysosomal enzymes.- #E-8 Investigation of tumour-invasion mechanisms.- #NC(E) Supplementary Items.- #NC(E)-1 Plasma membrane distribution of metalloproteinases and cysteine proteinases in metastatic human cancer cells.- #NC(E)-2 Proteases and oxidants in injury to alveolar epithelial cells caused by lung-derived neutrophils in vitro.- #NC(E)-3 Autophagy and protein degradation in rat hepatocytes, studied by means of subcellular fractionation in Nycodenz gradients.- #NC(E)-4 Immunochemical techniques in the study of protein degradation with particular reference to collagen.- #F Renal Investigations.- #F-1 A nuclear magnetic resonance approach to investigate the biochemical and molecular effects of nephrotoxins.- #F-2 Enzyme release in nephrotoxicity and renal disease.- #F-3 The investigation of subcellular derangements in nephrotoxicity.- #F-4 Heterogeneity and function of kidney cortex lysosomes.- #F-5 Involvement of kidney lysosomes in the nephrotoxicity of cadmium and other metals.- #F-6 Lysosomal populations in kidney cortex of rats with heavy proteinuria.- #F-7 Immune derangements in experimental, toxin-induced autoimmune nephropathies.- #F-8 Glomerular basement membrane and the inflammatory response.- #F-9 Biochemical and immunological characterization of basement membranes in renal disease.- #Nc(F) Supplementary Items.- #Nc(F) Supplementary Items.- with Sub-index.