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Cancer Drug Resistance on Hardback
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Cancer Drug Resistance

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Description

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.
Release date NZ
March 9th, 2006
Audience
  • Professional & Vocational
Contributor
  • Edited by Beverly A. Teicher
Illustrations
XVI, 617 p.
Pages
617
Dimensions
178x254x28
ISBN-13
9781588295309
Product ID
2043247

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