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B Cell Receptor Signaling

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Description

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, whilealso paving the way for eventually combating these diseases.

Author Biography:

Tomohiro Kurosaki, MD, PhD, is a professor at WPI Immunology Frontier Research Center at Osaka University, Japan Jürgen Wienands, PhD, is a professor of Cellular and Molecular Immunology at the University of Göttingen, Germany
Release date NZ
March 30th, 2018
Audience
  • Professional & Vocational
Contributors
  • Edited by Jurgen Wienands
  • Edited by Tomohiro Kurosaki
Edition
Softcover reprint of the original 1st ed. 2016
Illustrations
X, 231 p.
Pages
231
Dimensions
156x234x13
ISBN-13
9783319798998
Product ID
27848883

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