Professor Laurens Holmes Jr. was trained in internal medicine, specializing in immunology and infectious diseases prior to his expertise in epidemiology-with- biostatistics. He is an advocate of reality in modeling of epidemiologic, clinical and biomedical research data, consequential epidemiology, as well as explanatory ecologic model in understanding the complex etiologies of health and disease. Over the past two decades, Dr. Holmes had been working in cancer epidemiology, control & prevention with substantial publication on hormonally-related malignancies mainly prostate, thyroid, cervical, and testicular. Other areas where his focus had been during the last fifteen years include pediatric malignancy namely ALL, AML, lymphoma, brain and CNS. His involvement in chronic disease epidemiology, control and prevention includes signal amplification and stratification in risk modeling and health disparities in hypertension, and diabetes mellitus with large legacy (preexisting US National Health Statistics Center) data. Professor Holmes is a pioneer of health disparities epidemiology where he presents on disentangling race in epidemiologic studies by re-considering the biologic,bio-molecular, genetic, epigenetic determinants of disease incidence, prevalence, morbidity, prognosis, severity and mortality.