The thoroughly revised, updated Fifth Edition of this classic is the most comprehensive, current, and authoritative reference on all anticonvulsants available today. This edition features detailed profiles of newer drugs - including levetiracetam, oxcarbazepine, tiagabine, topiramate, and zonisamide as well as new chapters on the use of antiepileptic drugs in children and during pregnancy. Drugs are covered in alphabetical order and in an easy to follow format: mechanisms of action; chemistry, biotransformation, and pharmacokinetics; interactions; clinical efficacy and use; and adverse effects . Coverage of clinical use includes nonepileptic and psychiatric disorders where appropriate. This edition has been trimmed to a more manageable size by shortening the chapters on older or less frequently used drugs. Features: - The latest, comprehensive coverage of anti-epileptic drugs. - Structured and consistent coverage of each drug for ease of use. - Authoritative, must-have reference for clinicians who prescribe drugs regularly. New to this edition: - Drugs are covered in alphabetical order.
- Chapter on newer drugs including levetiracetam, oxcarbazepine, tiagabine, topiramate, and zonisamide. - Chapters on use of these drugs in children, women, and during pregnancy
Table of Contents
GENERAL PRINCIPLESChapter 1 Principles of Antiepileptic Drug Action Chapter 2 Neurophysiological Effects of Antiepileptic Drugs Chapter 3 Discovery and Preclinical Development of Antiepileptic DrugsChapter 4 Clinical Development of Antiepileptic Drugs: Medical Perspective Chapter 5 Clinical Development of Antiepileptic Drugs: Industry Perspective Chapter 6 Clinical Development of Antiepileptic Drugs: Regulatory Perspective Chapter 7 Principles of Epilepsy Treatment Chapter 8 Combination Therapy and Drug Interactions Chapter 9A Laboratory Monitoring of Antiepileptic DrugsChapter 9B Safety Monitoring of Antiepileptic DrugsChapter 10 Use of Antiepileptic Drugs in ChildrenChapter 11 Use of Antiepileptic Drugs in WomenChapter 12 Use of Antiepileptic Drugs in the ElderlyChapter 13 Treatment of Status Chapter 14 Outcomes and Pharmacoeconomics Chapter 15 Prevention of EpileptogenesisBENZODIAZEPINESChapter 16 Mechanisms of ActionChapter 17 Chemistry, Biotransformation and Pharmacokinetics Chapter 18 Clinical Efficacy and Use in Epilepsy Chapter 19 Adverse Effects CARBAMAZEPINEChapter 20 Mechanisms of ActionChapter 21 Chemistry, Biotransformation and Pharmacokinetics Chapter 22 Interactions with Other Drugs Chapter 23 Clinical Efficacy and Use in EpilepsyChapter 24 Clinical Efficacy and Use in Other Neurological Disorders Chapter 25 Clinical Efficacy and Use in Psychiatric Disorders Chapter 26 Adverse Effects FELBAMATEChapter 27 Felbamate GABAPENTINChapter 28 Mechanisms of ActionChapter 29 Chemistry, Biotransformation, Pharmacokinetics, and InteractionsChapter 30 Clinical Efficacy and Use in EpilepsyChapter 31 Clinical Efficacy and Use in Other Neurological Disorders Chapter 32 Clinical Efficacy and Use in Psychiatric Disorders Chapter 33 Adverse Effects LAMOTRIGINEChapter 34 Mechanisms of Action Chapter 35 Chemistry, Biotransformation, and Pharmacokinetics Chapter 36 Interactions with Other Drugs Chapter 37 Clinical Efficacy and Use in EpilepsyChapter 38 Clinical Efficacy and Use in Nonepileptic Disorders Chapter 39 Adverse Effects LEVETIRACETAMChapter 40 Mechanisms of Action Chapter 41 Chemistry, Biotransformation, Pharmacokinetics and Drug Interactions Chapter 42 Clinical Efficacy and Use in Epilepsy Chapter 43 Adverse Effects OXCARBAZEPINEChapter 44 Mechanisms of ActionChapter 45 Chemistry, Biotransformation, and Pharmacokinetics Chapter 46 Interactions with Other Drugs Chapter 47 Clinical Efficacy and Use in Epilepsy Chapter 48 Clinical Efficacy and Use in Nonepileptic Disorders Chapter 49 Adverse Effects PHENOBARBITAL and OTHER BARBITURATESChapter 50 Mechanisms of Action Chapter 51 Chemistry, Biotransformation, and Pharmacokinetics Chapter 52 Interactions with Other Drugs Chapter 53 Clinical Efficacy and Use in EpilepsyChapter 54 Clinical Efficacy and Use in Nonepileptic Disorders Chapter 55 Adverse Effects Chapter 56 Other Barbituates PHENYTOIN and OTHER HYDANTOINSChapter 57 Mechanisms of Action Chapter 58 Chemistry, Biotransformat
