Agent John Lost is one of the best agents of the ISA (International Security Agency), the international law enforcement arm of the United Nations that was once Interpol. He has enhanced abilities that makes him faster and stronger than most agents. He also has a brilliant mind that grants him the ability to understand any device almost intuitively and design anything he can imagine. However, as amazing as he is, John Lost lacks a couple important things, his ability to experience emotion and his memory of his past. He doesn't even know how he came to be superhuman. Fortunately, those particular flaws don't bother his partner, Abigail Summers, a woman whose own skills as an agent border on superhuman as well. It is not until John and Abigail come upon a bizarre case involving terrorists that John begins to learn what he'd come to believe was never true. The terrorists are not like any others he and his partner have faced, and while this is going on, John is being tracked by a mysterious woman he'd previously seen in visions. Learning the woman is real is only the start of the inevitable change in John's life. He later discovers he is, in fact, a new kind of humanoid called an Alterien. And he's not the only one.