In this issue of Clinics in Liver Disease, guest editor Dr. Ashwani K. Singal brings his considerable expertise to the topic of Alcohol-Associated Liver Disease. Portal hypertension is often one of the major complications seen in advanced liver disease. Top experts discuss various aspects of alcohol-associated liver disease (ALD), to provide comprehensive coverage on current status, update recent developments especially during the last decade, and highlight clinical and experimental unmet needs for practicing providers and for researchers in the field of ALD. Contains 18 relevant, practice-oriented topics including microbiome in ALD; diagnosis of alcoholic use disorder and of ALD; non-invasive tests in assessment of ALD patients; treatment of alcoholic use disorder: behavioral and pharmacological therapies; current medical treatment of ALD: pharmacological and nutrition; liver transplantation in ALD; digital technology and AI in management of ALD; and more. Provides in-depth clinical reviews on alcohol-associated liver disease, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.