Award-winning author and illustrator Don Brown explores the history of vaccines from smallpox to COVID-19 in this installment of the Big Ideas That Changed the World graphic novel series. A Shot in the Arm! explores the history of vaccinations and the struggle to protect people from infectious diseases, from smallpox—perhaps humankind’s greatest affliction to date—to the COVID-19 pandemic. Highlighting deadly diseases such as measles, polio, rabies, cholera, and influenza, Brown tackles the science behind how our immune systems work, the discovery of bacteria, the anti-vaccination movement, and major achievements from Lady Mary Wortley Montagu, who popularized inoculation in England, and from scientists like Louis Pasteur, Antonie van Leeuwenhoek, and Edward Jenner, the "father of immunology." Timely and fascinating, A Shot in the Arm! is a reminder of vaccines’ contributions to public health so far, as well as the millions of lives they can still save. Big Ideas That Changed the World is a graphic novel series that celebrates the hard-won succession of ideas that ultimately changed the world. Humor, drama, and art unite to tell the story of events, discoveries, and ingenuity over time that led humans to come up with a big idea and then make it come true. Read them all! Rocket to the Moon! Machines That Think! A Shot in the Arm! We the People! All Charged Up!