Trauma Center: New Blood welcomes two new playable characters, Markus Vaughn and Valerie Blaylock, both highly skilled doctors soon whisked to LA to investigate the epidemic of a new deadly disease - Stigma. Caduceus, the international organisation that treats and researches new diseases is called in, however they struggle to stop the disease from taking more lives. Markus and Valerie soon come to play an important part in unravelling a web of deceit and betrayal that could lead to lethal consequences.

Throughout Trauma Center: New Blood players are put in numerous enthralling situations where patients' lives hang in the balance. Players must strategically and skilfully use a set of medical instruments to operate on a wide variety of illnesses. Keeping one eye on the clock, operations must be successfully completed within a set time before advancing to the next chapter in the story. Budding surgeons can also choose the difficulty level. But beware, a harder skill level will see an increase in damage caused if mistakes are made and the stabiliser medication becomes less effective!

Using a combination of the Wii Remote and Nunchuk brings realism to a whole new level as players enjoy the lifelike use of surgical instruments, for example by simulating the real-life motion of using a defibrillator with both controllers. In addition to this, players can also look forward to some new procedures to further their medical knowledge. Manual CPR and skin grafting can now be attempted as well as a variety of new medications available to inject.

The Wii Remote is used to wield surgical tools with precision, making every operation a truly nerve-wracking process. In case of emergency, each character has a unique Healing Touch at their disposal. This allows players to briefly slow down time or stabilise the patient's vitals. It can only be performed once per operation and requires the player to swiftly and precisely draw a five-point star on the screen. Manual dexterity is further tested in tense operations where the Wii Remote must be carefully twisted to put broken bones back together. With more emphasis on realistic operations, Trauma Center: New Blood will have your heart racing as you struggle to save the lives of your ill-fated patients.

Trauma Center: New Blood will also see two players able to team up in almost every operation using co-operative play mode. Combine your talents with a friend or family member to save lives together as you operate simultaneously, each selecting instruments from your own set. Players can also compare their healing skills with the rest of the world as they upload scores to leaderboards via the Nintendo Wi-Fi Connection.