When an Assistant Sheriff's niece is found dead after she attends a popular nightclub, Lou Ann Jasinski, Homicide and Death Investigator is assigned the case at the behest of the Assistant Sheriff, her boss. A fatal drug overdose is suspected to be the cause of death. While Lou Ann investigates the young woman's suspicious death, her case load gets bigger when two other party-goers also succumb to the suspected new designer drug. FBI Special Agent Harry Boxer, Lou Ann's husband, busts a boat loaded with drugs with a novel, unknown drug among the booty. Joanna, a past sex trafficked victim, who Lou Ann and Harry have adopted into their family, is now an emergency room nurse. She witnesses the same overdose fatalities. The clock is ticking for Lou Ann and Harry to nab the drug traffickers responsible for the nightclub deaths before these goons threaten them and their family.