Excerpt from The Journal of Laboratory and Clinical Medicine, Vol. 1: October, 1915-September, 1916 But even better results have been obtained by the use of sensitized typhoid vaccines. These vaccines, which were originally suggested by Besredka in 1902, consist in either living or dead bacteria that have been treated, or sensitized, by means of an immune serum which is active against the organism in question, with subsequent removal of the excess of serum by washing. Such vaccines, particularly in the case of typhoid fever, have been shown, on the basis of the experimental work of numerous observers, to possess the following advantages over the ordinary, untreated vaccines. They give rise to transitory, passive im munity followed by active immunity that is as lasting as that secured by using untreated vaccines. They have the further advantage of producing distinctly less symptomatic disturbances than the ordinary vaccines. In their experiments on apes Metchnikoff and found distinctly better protection against typhoid fever, which can be produced in these animals, by vaccinating with liv ing, sensitized typhoid bacilli than by some of the other vaccines that have been devised, and used for the production of immunity in human beings. These sen sitized vaccines havesubsequently been extensively used for prophylactic im munization with success. In recent publications Gay and Claypole29 have shown that either living or dead sensitized typhoid vaccines, but particularly the sedi ment of the alcohol - killed sensitized vaccines, protect rabbits against becom ing typhoid carriers better than several other unsensitized preparations that were tried. For a further discussion of the use of these vaccines in prophy laxis, we refer the reader to this article. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.