Vol. 2 introduces the Medusa Guild, a league of powerful humans whose goal is to seal the doors to all the Mahgae's. We find out the name of the female human, Mahalisa. She and Henduh Kyung do more damage, as they try to find their way to the Mahgae. As some of the monsters die at the hands of the Medusa Guild, after dying, they come back to life transformed into more powerful monsters. Meanwhile, Sang tries to protect Notra from the humans because she doesn't want them to take Notra's ring. On a large boat that hovers in the air in front of the school stands Lance, who is leading this team of the Medusa Guild. Lance sees the trouble the two humans are having with the monsters and orders his team to move into phase 2. As Mordicus, Luka, and Tyrannus transform into stronger monsters, they wonder how they got their new powers and wonder if it isn't because of Sang, since these changes happened after they came into contact with her. Lance and his sergeant Gelpa descend onto the school grounds to help out. Meanwhile, Henduh Kyung kills Fatalis while Notra and Sang watch. Dev appears, after transforming into a very powerful monster, to avenge his brother's death.
There is a mysterious connection between Lance and Sang, he seems to know who Sang is and refers to her as Lady Sang. Vol. 2 ends with everyone wondering who Sang is as she seems to harbor some strong powers of her own.