This volume charts new methodological territories for rhetorical studies and the emerging field of the rhetoric of health and medicine. In offering an expanded, behind-the-scenes view of rhetorical methodologies, it advances the larger goal of differentiating the rhetoric of health and medicine as a distinct but pragmatically diverse area of study, while providing rhetoricians and allied scholars new ways to approach and explain their research. Collectively, the volume’s 16 chapters: Develop, through extended examples of research, creative theories and methodologies for studying and engaging medicine’s high-stakes practices. Provide thick descriptions of and heuristics for methodological invention and adaptation that meet the needs of needs of new and established researchers. Discuss approaches to researching health and medical rhetorics across a range of contexts (e.g., historical, transnational, socio-cultural, institutional) and about a range of ethical issues (e.g., agency, social justice, responsiveness).