Yee-haw! It's vampires in the Old West! It's 1870 in the Old West, and a group of zealots called the Anti-Vampire Mission - working under the banners of God and the president - wage war against the carriers of the "mad blood disease." It is a war that knows no bounds of decency. In this miserable, lawless district, a girl named Kyrie stands up to fight. Her father is the infamous "man in black," a vampire of great power that has been captured by the Anti-Vampire Mission. Kyrie also suffers from the mad blood disease, and she is pursuing her father - with the intention of killing him!