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Death Receptors in Cancer Therapy
Death Receptors in Cancer Therapy
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Death Receptors in Cancer Therapy

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Description

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.
Release date NZ
November 19th, 2010
Audience
  • Professional & Vocational
Contributor
  • Edited by Wafik S. El-Deiry
Edition
Softcover reprint of hardcover 1st ed. 2005
Illustrations
XII, 374 p.
Pages
374
Dimensions
178x254x20
ISBN-13
9781617374012
Product ID
9985756

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