American author Willa Cather was born and spent her first nine years in the Shenandoah Valley of Virginia. Here, as an observant daughter of a privileged white family, Cather first encountered differences and dislocations that remained lively, productive, and sometimes deeply troubling sites of tension and energy throughout her writing life. The essays in Cather Studies, Volume 14 seek to unsettle prevailing assumptions about Cather’s work as she moved from Virginia to Nebraska to Pittsburgh to New York City to New Mexico and farther West, and to Grand Manan Island. The essays range from examinations of how race shapes and misshapes Cather’s final novel, Sapphira and the Slave Girl, and challenges to criticisms of her 1935 novel, Lucy Gayheart. Contributors also frame fresh discussions of Cather’s literary influences and cultural engagements in the first decade of her career as a novelist through the lens of sex and gender and examine Cather’s engagements with region as a geopolitical, sociolinguistic, and literary site. Together, the essays offer compelling ways of seeing and situating Cather’s texts—both unsettling and advancing Cather scholarship.