Asymmetric synthesis has become a major aspect of modern organic chemistry. The stereochemical properties of an organic compound are often essential to its bioactivity, and the need for stereochemically pure pharmaceutical products is a key example of the importance of stereochemical control in organic synthesis. However, achieving high levels of stereoselectivity in the synthesis of complex natural products represents a considerable intellectual and practical challenge for chemists. Written from a synthetic organic chemistry perspective, this text provides a practical overview of the field, illustrating a wide range of transformations that can be achieved. The book captures the latest advances in asymmetric catalysis with emphasis placed on non-enzymatic methods.
Topics covered include:* Reduction of alkenes, ketones and imines* Nucleophilic addition to carbonyl compounds* Catalytic carbon-carbon bond forming reactions* Catalytic reactions involving metal carbenoids* Conjugate addition reactions Catalysis in Asymmetric Synthesis bridges the gap between undergraduate and advanced level textbooks and provides a convenient point of entry to the primary literature for the experienced synthetic organic chemist.
Dr Vittorio Caprio is Lecturer in Organic and Medicinal Chemistry in the Department of Chemistry, University of Auckland, Auckland, New Zealand